Adolescence is one of the two periods of an individual’s life span, where there are very large physical changes, namely the maturation of reproductive organs and functions. This behavior can have a detrimental impact on adolescents themselves, such as contracting STIs and HIV and AIDS, pregnancy out of wedlock, abortion, physical, social, and psychological disorders. The results of the WHO survey in 2015 averaged 44.1 deaths among female adolescents aged 15-19 years due to sexual behavior and reproductive health problems. Meanwhile, the average death rate for adolescents (15-19 years) due to childbirth in Indonesia is 47 people. This study analyzes the relationship between knowledge, attitudes, and access to information on reproductive health issues with adolescent sexual behavior. The method used is Meta-analysis by searching the Google Scholar database. After going through the identification and selection stages, 13 articles were included in the meta-analysis. Pooled Odds Ratio (POR) was calculated using a fixed-effect model for data analysis according to the heterogeneity test using Review Manager 5.4.1. Based on the review, the POR value for knowledge is 2.07 (95% CI 1.29-3.33), attitude 2.17 (95% CI 1.04-4.56), and Information Media 3.95 (95% CI 1.81-8.861), so that it can be concluded from the three variables studied, the information media variable has a stronger effect than the knowledge and attitude variables towards adolescent sexual behavior.

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