Malaria is an infectious disease because of Plasmodium Sp., and the Anopheles mosquito spreads it. Anopheles lives and breeds in the field, forest, and river/beach. People who can be suffered from malaria are about 41% in the world. One of the developments of malaria research can be done in an animal model. This research’s goal was to make an animal model of malaria infection by analyzing the differences of parasite number and bodyweight of Mus musculus from day 0 until day 4 of infection. The research method was experimental using post-test only with control group design and time series. Several Mus musculus was 18/group. Infection of P. berghei was injected intraperitoneal in Mus musculus; it was called day 0. The dose was 107 of the parasite in 0.2 ml of blood. The control group and infection group’s parasite number and body weight were done daily from day 0 until day 4. Examination of parasite used thick and thin blood smear. Bodyweight of Mus musculus was examined by a digital scale. The result was significant differences of parasite number in infected in Mus musculus among day 0, 1, 2, 3 and 4 (p = 0.031). The highest parasite numbers were on day 4 (25.44). There was significant difference of body weight in the control group (p = 0.000), and also in infection group (p = 0.000). The conclusion was P. berghei infection could be used to induce malaria infection in Mus musculus.

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Istiana and M. S. Noor, “Evaluation of Parasite Number and Bodyweight in Mus musculus which was Infected by Plasmodium Berghei,” International Journal of Health and Medical Sciences, vol. 4, no. 1, pp. 22-27, 2018. doi: https://dx.doi.org/10.20469/ijhms.40004-1